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In fact, an animal model with genetic deficiency of TNFα in DOCA-salt hypertension demonstrated a significant reduction in the expression of inflammatory markers IL-1β, monocyte chemoattractant protein-1 and monocyte/macrophage marker F4/80, and a decreased expression of NADPH isoforms, gp91phox and p22phox, NADPH isoforms and prevented the reduction of eNOS in vascular tissue (Reference Cai, Hao and Liu54)
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