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Although IGF2 gene expression is not under GH control, the circulating levels of IGF-II are largely influenced by GH status since IGF-II (as well as IGF-I and IGFBP-3) is rapidly cleared from the circulation if not bound in the ternary complex
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A 2025 paper in Biogerontology characterised that epitalon increased telomere length in human cell lines through telomerase upregulation (PMID 40908429)
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