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Drugs commonly prescribed, including dexamethasone (DEX), clotrimazole, and rifampicin, induce CYP3A4 expression by activating PXR directly as agonist (clotrimazole and rifampicin) and indirectly through other receptors such as glucocorticoid receptor (GR) (DEX), leading to drug-drug interactions in which one drug accelerates the metabolism of another, potentially causing adverse effects [16]

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