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After co-culturing with MSC-derived microvesicles, increased levels of M2 markers and fewer LPS-induced pro-inflammatory cytokines were detected in BV-2 cells, indicating their role in the phenotypic transition from M1 to M2 (163)

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Injection site reactions — redness, itching, a small welt — are the most commonly reported adverse effect, and they are more frequent with more concentrated preparations, which is a second argument for generous dilution