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Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model - ScienceDirect

10.1016/j.freeradbiomed.2021.05.009 Free Radic Biol Med

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By binding to the IGF-1 receptor (IGF1R), IGF-1 initiates the phosphorylation of phosphatidylinositol 2-phosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which activates downstream signaling pathways involving AKT and the mammalian target of rapamycin (mTOR)

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