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In addition to improving lipid levels, some research suggests statins, particularly atorvastatin, reduce low-grade inflammation and high testosterone levels in women with polycystic ovary syndrome

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However, mutational analysis demonstrated that androgen driven upregulation of IGF-1R was not driven by AR genomic activity but involved the activation of the Src-extracellular signal-regulated kinase pathway (Pandini et al., 2005)