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Imbalances in the plasma level of glycine as well as other AAs have also been shown in obesity (Newgard et al , 2009), T2D (Wang et al , 2011a), and NAFLD (Kalhan et al , 2011)

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In this review, we provide an in-depth exploration of the GDF11 function and its controversy, which may inform future studies on the biological role of GDF11 and its potential limitations in disease treatment and prevention