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CPZ ( bis -cyclohexanoneoxalyhydrazone) is a well-established demyelinating toxicant, inducing consistent and widespread demyelination in vivo following 6 weeks of daily 0.2–0.3% CPZ treatment that can be reversed by endogenous remyelination occurring on cessation of treatment (Blakemore, 1972

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Any preparation or experimental handling should take place exclusively within a suitable controlled laboratory environment and in accordance with the requirements of the intended research protocol