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In the effort to characterize the binding site of Gβγ in GIRK channels, cross-linking experiments revealed the binding of four Gβγ subunits per tetramer, with each Gβγ binding to one channel subunit (Sadja et al., 2002)

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These studies demonstrate the utmost importance of aspartate in cancer and have motivated the development of inhibitors of aspartate aminotransferases as potential cancer therapeutics [92,93]

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