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BDNF acting as a neuromodulator facilitates synaptic plasticity via multiple mechanisms including the modulation of calcium dynamics, which regulate AMPAR trafficking [159] and retrograde signaling [160], attenuation of synaptic fatigue [161], excitability regulation of induction threshold [162], suppression of inhibitory transmission [163], neuronal synchronization by diminishing spike time jitter [164], functional synaptic clustering [165], and suppression of autophagy [166]