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In parallel, the expression of mitochondrial fusion proteins, including mitofusins 1/2 (Mfn1/2) and optic atrophy 1 (Opa1), decreased from 5 months to 12 months and increased from 12 months to 24 months, suggesting that synaptosomal mitochondria were shifted to a pro-fusion state in aged animals

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This enrichment was associated with increased TPI1 protein levels in CRC cells and elevated glycolytic activity (Figure 4) (Zhao et al., 2016)