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In aggregate, NNMT performs a pro-tumor role in PAAD as a downstream target of aberrantly activated Hedgehog signaling, but the concrete mechanisms urgently need to be elucidated, which will aid in discovering novel therapeutics and treatments for PAAD patients
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Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice
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