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By generating l-citrulline, which is subsequently metabolized to the NOS substrate l-arginine by the concerted action of argininosuccinate synthetase and argininosuccinate lyase in the kidney, Gln also functions as an l-arginine precursor to drive NO synthesis [15]
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Another gut microbial-derived metabolite, capsiate, alleviates ferroptosis induced by intestinal I/R injury by promoting GPX4 expression through the activation of transient receptor potential cation channel subfamily V member 1 [88]
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