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Most importantly, infarct size is reduced to 26%, versus 48%–53% for free drug groups, representing a 48%–51% reduction relative to free drugs, demonstrating that RGD-S/P-LPNs meaningfully advance cardioprotection through dual-drug synergy, sustained release, PEGylation, and active αvβ 3 integrin targeting (Qiu et al., 2017)