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63 The accumulated NAPQI depletes GSH in the endoplasmic reticulum to induce an oxidation–reduction imbalance, which initiates the phosphorylation of eukaryotic initiation factor 2α (eIF2α) to activate ATF6 and CHOP, eventually resulting in hepatocyte apoptosis (Figure 2)

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5 also demonstrated that riboflavin alone without iron supplementation was effective in improving hematologic status in young women in the United Kingdom