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Marked elevations in liver function test results (e.g., AST [SGOT] and ALT [SGPT]), occurred on 2 occasions following administration of high doses (total doses: 106 and 250 g over 3-4 days) of acetylcysteine rectally and via nasogastric tube in a 3-year-old boy with cystic fibrosis

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[38] found that NAC substantially reduced overall symptom ratings in schizophrenia in three RCTs involving 307 subjects (NAC: 153, placebo:154)