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By modulating actin dynamics, TB-500 promotes cell migration (chemotaxis and haptotaxis), cytoskeletal reorganization, and motility of key repair cells like fibroblasts, endothelial cells, keratinocytes, and stem/progenitor cells

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Inhibiting FGF-2 + tumors by dual blocking VEGF and PDGFRβ Since imatinib targets a broad-spectrum of kinases, its synergistic antitumor effects with VEGF blockade might involve inhibition of multiple kinases other than PDGFR