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JCI Insight 4 , e127647 (2019)

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Oxidative stress is a pivotal factor associated with compromised immunity and the intensification of inflammatory responses, thereby facilitate the pathogenesis of mastitis ( Figure 1 Given the complex genetic mechanisms of mastitis, the erythroid-2 related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/KEAP1) signaling pathway has received significant attention due to its crucial role in regulating antioxidant responses and reducing oxidative distress ( 2 Methodology This review article was synthesized based on an extensive examination of literature primarily published from 2018 to 2024