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In a 24-week trial, obese subjects receiving zonisamide (400 mg/d) + bupropion (300 mg/d) achieved more weight loss than zonisamide (400 mg), bupropion (300 mg), or placebo (−9.2, −6.6, −3.6, and −0.4%, respectively)

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[PubMed] [Google Scholar] Sikiric P, Separovic J, Anic T, et al