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This tolerance partly explains the alertness of chronic alcohol users at blood alcohol levels that, in others, would cause coma or death [238,239,240,241]
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In addition to this demonstration that the reduction of TGFb signaling was protective against aSyn-induced toxicity, we found that the opposite (i.e., stimulation of TGFb signaling by ligand treatment) was detrimental in our PD cell model
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