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In addition, Co-IP followed by mass spectrometry of mouse liver showed that the NNMT-interacted with betaine-homocysteine methyltransferase (BHMT), fructose 1,6 bisphosphatase 1 (FBP1), dihydroxyacetone kinase (DAK), methionine adenosyltransferase 1a (MAT1A), heat shock protein A8 (HSPA8), solute carrier transporter mitochondrial (citrate) (SLC25A1), selenium binding protein 2 (SELENBP2), and adenosylhomocysteinase (AHCY) [40]