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For women with heavy menstrual bleeding, discuss management options with a gynecologist—reducing blood loss preserves iron and hemoglobin

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Previous studies have shown that the PI3K/AKT signaling pathway plays anti-neuroinflammation, anti-oxidative stress and anti-apoptosis roles in neurons and increases AKT signaling, which inhibits the release of proinflammatory cytokines [42,43,44]