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In the G q signaling propagating path, TUG891 forms π-π interactions with the consecutive residues F88 2.53 and F311 7.43 in the binding pocket, along with the cytoplasmic side hydrophobic packing between Y227 5.58 and Y321 7.53 , enabling an outward tilt of TM7 and an inward tilt of TM1 (Fig
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