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In AD and PD, chronic activation of microglia and astrocytes leads to a sustained release of inflammatory mediators that contributes to neuronal death and the progression of neurodegeneration [239–241]
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Glutathione peroxidase 4 (GPX4) is a selenoenzyme that uses GSH as a co-factor to regulate lipid peroxidation of cell membranes during increased oxidative stress
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![PDF] Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial](https://figures.semanticscholar.org/e338e8f8bf819030be1ae81167c7d20946acbbb5/7-Table2-1.png)
