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People with Absorption Issues: Conditions like Crohn’s disease, celiac disease, or those who’ve had gastrointestinal surgery may struggle to absorb B12 efficiently through diet alone

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[2] Hepatic Concerns In rodent studies using doses 5-10 times higher than proposed therapeutic levels, approximately 8-12% of subjects showed elevated liver enzymes (ALT increases of 2-3 times upper normal limits) after 4-6 weeks of daily administration