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NaBPC157 was applied as a prophylactic co-treatment or therapeutic salutary regimen (10 µg or 10 ng/kg i.p.)

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In a lipopolysaccharide (LPS)-induced acute lung injury model, intravenous administration of FLuc-mRNA loaded lung-AO 12 LNPs maintained 77% of the luciferase expression compared to that observed in healthy lungs, whereas lung-cLNPs retained only 49% protein expression (Fig