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Several compounds based on gut peptides now in development for the treatment of obesity are reviewed, including Nastech's intranasal PYY (3–36) , 7TM Pharma's TM30338, and Amylin Pharmaceuticals' Pramlintide

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Historically, we have used a value of 0.80 for the loss-sharing ratio, which, we believe, preserves incentives for agencies to attempt to provide care efficiently for outlier cases