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Monitoring nutrient status while on tirzepatide with B12 Baseline laboratory assessment before starting tirzepatide should include B12 levels, complete blood count (CBC), comprehensive metabolic panel (CMP), lipid panel, and HbA1c if you have diabetes or prediabetes

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While waiting for the results of confirmatory trials, it seems reasonable to consider folic acid with or without vitamin B12 supplementation as appropriate adjunctive therapy in patients with CKD