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Corroborating these results, accumulated evidence has shown that NOX4 is a critical regulatory gene for expressing inflammatory mediators in vascular smooth muscle cells (VSMC) in aging, being a critical factor for the development of CVDs age-related atherosclerotic severity [63]
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In women of reproductive age, exposure to TCS is of particular concern given the ability of TCS to cross the placenta and fetal blood-brain barrier and enter breast milk [37]
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