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A dynamic loop at the active center of the Escherichia coli pyruvate dehydrogenase complex E1 component modulates substrate utilization and chemical communication with the E2 component

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[1] Biomarkers such as p16INK4a expression, β-galactosidase activity, and inflammatory cytokine levels (IL-6, TNF-α) are monitored to assess senescent cell clearance efficacy