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14, 15, 16, 17, 18, 19, 20 Redox imbalance in SZ patients Genetic studies have shown associations between oxidative stress gene polymorphisms and SZ, 21, 22 including genetic variations in glutathione cysteine ligase (GCL) and several glutathione-S-transferases, 23, 24, 25 both involved in the synthesis of the endogenous antioxidant glutathione