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The most well-known circadian clock gene is CLOCK (circadian locomotor output cycles kaput), which helps regulate circadian rhythm by controlling the expression of other circadian clock genes including BMAL1 (brain and muscle Arnt-like protein-1), PER1 and PER2 (Period 1 and Period 2), CRY1 and CRY2 (cryptochrome 1 and cryptochrome 2), and others

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To prevent this damage, organisms from all domains of life have antioxidants that function to detoxify and regulate ROS in reduction reactions 6