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Sublingual administration, which bypasses the gastrointestinal tract, appears to be equally effective as IM injections while being less invasive and more cost-efficient—particularly in patients with atrophic gastritis, post-gastrectomy status, or conditions that impair intrinsic factor-mediated absorption, where long-term intervention is often required

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6–9 As a class, DOACs have been shown to be superior or non-inferior to warfarin in terms of efficacy, 10,11 with reduced risk of stroke, intracranial bleeding, and all-cause mortality