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In ECs, G i , or G q -coupled GPCRs, increase, PI3K-Akt signaling and activate eNOS by phosphorylation at Ser 1177

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In splenocytes from WT mice, pretreatment of MS (0.4 mM, Gpx inhibitor) for 48 h inhibited Con A-induced cytokines such as IL-2, IFN- γ and TNF- α (Figure 7a)

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