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Here, proton gradient-driven OXPHOS produces numerous ATP, underscoring the tight coupling between the TCA cycle and mitochondrial respiration ( The shift from TCA cycle entry to lactate production is linked to the inhibition of pyruvate dehydrogenase (PDH) by pyruvate dehydrogenase kinase 1 (PDK1)

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Because glutathione molecules have limited ability to penetrate deeply through the skin, the result remains superficial