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TFAM binds to mtDNA and forms a nuclear-like structure, thereby protecting mtDNA from the adverse effects of Aβ toxicity and oxidative stress, inhibiting the vicious cycle of neuronal mitochondrial dysfunction, and thus improving the pathophysiology of Alzheimer’s disease (Oka et al., 2016)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Li Z, Maglione M, Tu W