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Enhancing Cancer Therapy with Hyperthermia: Synergistic Effects with Natural Compounds and Conventional Treatments - PMC
[DOI] [PubMed] [Google Scholar] 371.Li G., Han N., Yang H., Wang L., Lin X., Diao S., Du J., Dong R., Wang S., Fan Z
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Voriconazole C min of 1–5 μg/mL, posaconazole C min of ≥0.7 μg/mL, itraconazole C min of ≥0.5 μg/mL, busulfan AUC of 900–1,500 μM min, cyclosporine C min of 200–400 ng/mL, tacrolimus C min of 5–15 ng/mL, and sirolimus C min of 3–8 ng/mL are used as the therapeutic index for individualized treatment ( 3 Results 3.1 PBPK model building and evaluation The PBPK models of three immunosuppressants (cyclosporine, tacrolimus, and sirolimus), one chemotherapeutic agent and its anticonvulsant prophylactic agent (busulfan and phenytoin), four antifungal agents (voriconazole, posaconazole, itraconazole, and fluconazole), one antiviral agent (letermovir), two antiemetic agents (fosaprepitant and aprepitant), and omeprazole were developed and comprehensively evaluated using the blood concentration-time profiles