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In this section, we wish to refer to the mechanism of reaction between heme (a rather vital molecule for life [189]), and particular its oxidized forms (hematin and hemin (ferric chloride heme)) and GSH as well as the consequences of this conjugation on the cytotoxic actions of the endogenous, electrophile, free heme

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However, as a precautionary measure, patients with severe kidney disease or those with known cyanide metabolism disorders are sometimes advised to use alternative B12 forms

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