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Premium Grape Regions Are Holding Cost Floors In July 2025, El Dorado County reported that its 2024 wine grape production fell 5.1% to 5,529 tons from 5,826 tons in 2023, while the average price per ton increased 3.4%, from US$1,985 to US$2,053
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590 These examples illustrate how protein misfolding within the secretory pathway compromises lysosomal function, organelle homeostasis, and cellular viability, as previously described for membrane proteins such as CFTR in cystic fibrosis (see Section “Errors in the protein synthesis pathway”)
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