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Introduction Autoimmune diseases are complex diseases characterized by the loss of immunological tolerance to self-antigens and sustained aberrant immunological response against healthy cells and tissues, leading ultimately to the overproduction of autoreactive immune cells and/or autoantibodies ( CD8+ T cells, also called cytotoxic T lymphocytes (CTL), are one subtype of T cell ( Epigenetics refers to stable and heritable changes in gene expression without involving changes in DNA sequence, which are thought to be connection between environment factors and genetics ( In summary, this review aims to highlight the epigenetic role of CD8+ T cells in the pathogenesis of autoimmune diseases

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Addressing these limitations through structural engineering, surface modification and rigorous preclinical validation will be crucial for the future development of polysaccharide-based nanomedicines