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Opposite to the effects of GRK inhibition, a PKC inhibitor blunted short-term analgesic tolerance to morphine but not DAMGO (Hull et al., 2010), and in locus coeruleus neurones, cellular tolerance to DAMGO was not reversed by PKC inhibitors (Bailey et al., 2009a)
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Reprogramming, also known as polarization or alternate phenotype, is the process of changing the macrophage phenotype in response to the microenvironment or an active pathogen 87
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