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Retinoids including all-trans retinoic acid (ATRA), 13-cis-retinoic acid, and the synthetic analogs isotretinoin, etretinate and acitretin, which function through nuclear retinoic acid receptor, have been employed for over three decades to treat CTCL, with bexarotene as the first retinoid approved by the US FDA for CTCL therapy

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Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells