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[DOI] [PubMed] [Google Scholar] 60.Ng TB, Liu F, Wang ZT

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According to the characteristics of OCs and synovial macrophages, novel CEL-loaded PRNPs (CEL-PRNPs) were synthesized that contained celastrol (CEL), which can induce apoptosis in OCs and macrophages, RGD, which is a ligand of αvβ3 that targets OCs and inflammatory macrophages, and polyethylene glycol (PEG), which is cleaved by MMP-9