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The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis

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Recently, two isoflavonoids lupinalbin (IC 50 = 39.7 ± 1.5 µM), and 2′-hydroxygenistein-7-O-gentibioside (IC 50 = 50.0 ± 3.7 µM) from Apios americana were identified as competitive inhibitors, with K i values of 10.3 ± 0.8 µM and 44.2 ± 1.7 µM, respectively 266