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Factors produced by endothelial cells like nitric oxide activates the Notch pathway in glioblastoma, cancer-associated fibroblasts produce hepatocyte growth factor, osteopontin, and stromal-derived factor 1α, which activates the WNT pathway in colorectal cancer (43,44)
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It is also the best argument for buying smaller BAC water vials rather than one large one, since a 10 mL vial opened fresh for each mix beats a 30 mL vial slowly running down its clock in a drawer
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