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Evaluation of pain may include different pain assessment tools, such as Numerical Rating Scale (NRS), pain Visual Analog Scale (VAS), McGill´s Pain Questionnaire (MPQ) and short form MPQ, Pain Disability Index (PDI), Cold Intolerance Symptom Severity (CISS) Scale, Patient-Reported Outcome Measurement Information System (PROMIS) with subsets Pain Intensity, Pain Interference, Pain Behavior, and Neuropathic Pain Quality Scale, as well as the questionnaires Douleur Neuropathique 4 (DN4) and HQ-8 [70,72,73]

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F-actin is considered to be crucial for cell structure and function and promotes cell migration