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the sirtuins assistance in transcription: it is known that the silent information regulator‐1 (SIRT1) activates the PGC‐1α‐mediated transcription of nuclear and mitochondrial genes encoding for proteins during mitochondria proliferation, oxidative phosphorylation and energy production, while SIRT3 stimulates the proteins important for oxidative phosphorylation, tricarboxylic acid cycle and fatty‐acid oxidation, and indirectly, the PGC‐1α and AMPK