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93 In a later study, 239 patients were injected with local anesthetic of bupivacaine and betamethasone demonstrated significant reduction of pain in 45% of patients for 2 to 4 months and 15% having 8 months or longer with significant improvement of pain

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BPC-157’s primary signalling mechanisms are well-characterised: it activates VEGFR2, drives downstream ERK1/2 phosphorylation, and stimulates nitric oxide synthesis via the Akt-eNOS axis — producing pro-angiogenic, fibroblast-activating, and extracellular matrix-stabilising effects in experimental models