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In the CNS, thiamine deficiency can lead to Wernicke’s encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

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[DOI] [PubMed] [Google Scholar] 40.Chen X., Wang R., Zee P., Lutsey P.L., Javaheri S., Alcántara C., Jackson C.L., Williams M.A., Redline S