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Specifically, IFN-γ activates macrophages, neutrophils, and dendritic cells (DC) to destroy intracellular pathogens by producing reactive oxygen species (ROS), reactive nitrogen species, and antimicrobial peptides

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In addition to phosphate, many other so-called uremic toxins, that is substances which accumulate in the uremic state, are known to interfere with vitamin D metabolism and action (59,60)